PMC

Details of the ExAblate 2100 Breast coil and set up of the FUS table. a Breast coil table is placed on the patient’s treatment table. b Cooling coil insert in the center hole of the breast coil table. Cooling coil inner diameter is 152 mm, coil outer dimensions are 650 × 195 mm, coil height is 39 mm, and weight of cooling coil is 6.4 Ibs. c Patients were placed in the prone position on the FUS treatment table with the targeted breast placed in the water-filled cooler

Heat exchange devices (“cooling chips”) for gyral and sulcal cooling. A coil-design gyral cooling chip is shown in a side (A) and bottom view (B). A drawing of the side (C) and bottom (D) of the device shows components labeled. The device consists of silicon tubing embedded in PDMS that can be trimmed to size during surgery. Preformed ports provide access to cortex below the cooling chip for microthermocouples and/or electrodes. A typical small coil design chip weighs about 0.4 g. Sulcal loop designs are shown from a side (E) and front view (G), and drawings of these sulcal chips are shown in F and H. The PDMS serves to insulate the opposite bank of the sulcus from cooling. The sulcal loop design (E–H) is smaller (0.16 g) than the coil design. For all of these cooling devices, microthermocouples and/or electrodes are positioned after the cooling chip is in place.

The coil as positioned inside dewar, mounted to coil ring via cooling straps, with voltage instrumentation shown. Details of voltage tap connections are shown in insets.

Coil as positioned inside dewar, mounted to coil ring via cooling straps, with temperature instrumentation shown. Details of the temperature sensor connections are shown in insets.